SGIP1 — SH3GL interacting endocytic adaptor 1
SGIP1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SGIP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | NFAT-cAMP Signaling Inflammatory | ACKR3, ADGRE2, ANKRD28, CHSY1, CREM, ELL2, FRMD4A, GPCPD1 +3 more | View in SCUBA |
| Lymphatic endothelial | ECM-driven Migration migration & adhesion | FMNL2, GLIS3, LAMC1, MAML2, PCSK6, RAPH1, ST3GAL6, STK32B +2 more | View in SCUBA |
| Pericytes | Pericyte Inflammatory Activation Inflammatory | BATF3, CRISPLD2, FILIP1L, KCNJ8, MARCKS, PAG1, PDGFA, RHOBTB3 +3 more | View in SCUBA |
About the gene
| Synonyms | DKFZp761D221 |
|---|---|
| Chromosome | 1: 66533267-66751139 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Endocytosis |
Function
May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.