ST3GAL6 — ST3 beta-galactoside alpha-2,3-sialyltransferase 6
ST3GAL6 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ST3GAL6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Glial cells | ECM Homeostatic Regulation ECM remodeling | BPTF, KCTD12, MAPRE2, OAF, SASH1, TIMP2, TTC3 | View in SCUBA |
| Lymphatic endothelial | ECM-driven Migration migration & adhesion | FMNL2, GLIS3, LAMC1, MAML2, PCSK6, RAPH1, SGIP1, STK32B +2 more | View in SCUBA |
About the gene
| Synonyms | SIAT10, ST3GALVI |
|---|---|
| Chromosome | 3: 98732236-98821201 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Glycosyltransferase, Transferase |
Function
Transfers the sialyl residue from CMP-N-acetyl-beta- neuraminate to the terminal galactose residue on sugar chains of glycoproteins and glycolipids. It's alpha-2,3-sialyltransferase activity is specific toward type II glycan chains (Galbeta1-4GlcNAc) on glycoproteins and glycolipids such as neolactosides nLc4Cer and nLc6Cer, whose sialyl-products serve as precursors for the Lewis X antigen. Critically involved in the synthesis of functional selectin ligands needed for neutrophil recruitment during inflammation and lymphocyte homing to the lymph nodes (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.