ECM-driven Migration
Gene co-expression module in Lymphatic endothelial
| Category | migration & adhesion |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 11 genes have a known function matching the annotation |
Why this annotation
FMNL2 (formin-like 2, actin polymerization at lamellipodia/invadopodia driving cell migration), RAPH1 (lamellipodin, Rac1 effector promoting leading-edge actin), and LAMC1 (laminin gamma-1, basement membrane ECM) define a cell migration and ECM interaction program. MAML2 (Notch transcriptional coactivator) links to Notch-driven lymphangiogenesis. PCSK6 processes BMP/VEGF-related precursors. TBC1D8 and TBC1D15 (Rab GAPs) regulate endosomal trafficking of integrins/receptors supporting migration. ST3GAL6 (sialyltransferase) modifies surface glycoproteins affecting adhesion. SGIP1 regulates endocytosis. Neighbor context: FMNL2/RAPH1 directly parallel TRIO/NHSL1 in M44, confirming a migratory cytoskeletal neighborhood; LAMC1 adds an ECM/basement membrane dimension.
Genes
FMNL2, GLIS3, LAMC1, MAML2, PCSK6, RAPH1, SGIP1, ST3GAL6, STK32B, TBC1D15, TBC1D8
Most correlated modules
- ZEB1-driven EMT · correlation 0.89
- Hippo-Adhesion Signaling · correlation 0.88
- Chromatin Remodeling · correlation 0.88
- Actin-based Migration · correlation 0.86
- MAPK-ERK Signaling · correlation 0.86
- Actomyosin Contractility · correlation 0.83
- NF-κB Innate Signaling · correlation 0.79
- Basement Membrane ECM · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.