PRAM1 — PML-RARA regulated adaptor molecule 1
PRAM1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PRAM1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Multipotent Progenitor State Stemness | CD44, CD99, FLT3, GBP2, GLIPR1, IL6R, PLCB1, PROM1 | |
| Innate lymphoid cells | ILC1 Lymphocyte Signaling Immune regulation | CDIPT, CNPY3, DBNL, ENG, IL16, LIMD2, LSM2, MAPKAPK3 +11 more | View in SCUBA |
| Monocytes | Myeloid Activation Innate immunity | CCDC88B, GAS7, IL17RA, ITGAM, LTB4R, PSTPIP1, TMEM91 | View in SCUBA |
| Neutrophils | Endocytic Vesicular Trafficking Vesicular traficking | CLINT1, DNAJC13, LNPK, PHACTR2, PRKAA1, PTPN22, SEC63, VCL |
About the gene
| Synonyms | PML-RAR |
|---|---|
| Chromosome | 19: 8490056-8502640 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.