POLD2 — DNA polymerase delta 2, accessory subunit
POLD2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
POLD2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Glycolysis Biosynthesis Mitochondrial & OxPhos | EIF3I, FABP5, LDHA, MDH1, MRPL17, PAICS, PKM, PRDX1 +4 more | View in SCUBA |
| Endothelial | DNA Replication Cell cycle | CENPX, DNMT1, ICMT, IDH2, MCM3, MCM4, MCM5, MCM6 +11 more | View in SCUBA |
| Gamma-delta T cells | mRNA Splicing & Trafficking RNA processing & translation | ARF1, ARL6IP1, ARRDC2, B3GNT2, C17orf49, CCDC12, CWC15, DDX39A +19 more | |
| Innate lymphoid cells | Lipid & Isoprenoid Metabolism Metabolism | ARL6IP1, CHCHD5, ECH1, FDPS, GTF2H5, LYPLA1, NECAP2, NUBP2 +8 more | View in SCUBA |
About the gene
| Chromosome | 7: 44114631-44124358 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Biological process | DNA damage, DNA excision, DNA repair, DNA replication |
Function
Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex. As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Pol-delta3 and Pol- delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4. Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'- blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated. Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol- delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the DNA polymerase zeta complex. Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.