PTRH1 — Peptidyl-tRNA hydrolase 1 homolog
PTRH1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PTRH1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Effector Cell Migration migration & adhesion | ADAM15, ADAM8, ANXA2, APOBEC3G, CD52, CTSC, DSTN, FUT11 +17 more | |
| Mucosal-associated invariant T cell | Oxidative Stress Response Stress | ATIC, CD244, CYTH4, EIF2S2, GPR68, GSDMD, ING4, KEAP1 +11 more |
About the gene
| Synonyms | C9orf115, PTH1 |
|---|---|
| Chromosome | 9: 127690348-127724873 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, RNA-binding, tRNA-binding |
Function
Peptidyl-tRNA hydrolase that cleaves nascent chains-tRNAs that are not stably fixed in the P-site of 60S ribosome-nascent chain complexes. Acts downstream of the ribosome-associated quality control (RQC) pathway to release non-ubiquitinated nascent chains from 60S and 80S ribosome-nascent chain complexes. Does not act on ubiquitinated nascent chains, which are cleaved by ANKZF1 for degradation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.