RECK — Reversion inducing cysteine rich protein with kazal motifs
RECK belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RECK's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | EC Cytoskeletal Scaffold Cytoskeletal | ADD3, ANTXR2, CTSD, EPB41L2, FXYD6, GYPC, MAP4K2, NRP2 +2 more | View in SCUBA |
| Fibroblasts | TGF-beta Response ECM remodeling | C1orf21, CBR3, CNRIP1, DOK5, FREM1, GUSB, HTRA1, LRRN4CL +7 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic Valve Development Valve formation | GPM6A, LRP5, MEF2C, MPP7, NFIA, NFIB, PGM5, PRKAR1B +5 more | View in SCUBA |
About the gene
| Synonyms | hRECK, ST15 |
|---|---|
| Chromosome | 9: 36036913-36124455 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted membrane proteins |
| Molecular function | Protease inhibitor, Serine protease inhibitor |
| Biological process | Wnt signaling pathway |
Function
Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7. ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity. Also inhibits metalloproteinase activity of MMP2 and MMP14 (MT1-MMP).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.