S100 Alarmin Response
Gene co-expression module in Neutrophils
| Category | Inflammatory |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
S100A4, S100A6, S100A12 are S100 calcium-binding proteins with roles in neutrophil activation, inflammation, and damage-associated molecular pattern (DAMP) signaling. S100A12 is particularly a neutrophil-specific alarmin. CD177 is a neutrophil-specific activation marker. RBP7 is expressed in myeloid cells. MS4A6A is a myeloid differentiation marker. H2AC6 is a histone. The module coherence is moderate, with several genes showing weak/moderate membership, suggesting a mixed but inflammation-related program. The S100 family dominance with CD177 points to an activated/inflammatory neutrophil state releasing alarmins.
Genes
CD177, H2AC6, METTL9, MS4A6A, RBP7, S100A12, S100A4, S100A6, SH3BGRL3
Most correlated modules
- Neutrophil Motility Cytoskeleton · correlation 0.86
- Neutrophil Differentiation · correlation 0.85
- Actin Cytoskeleton Dynamics · correlation 0.75
- Specific Granule Release · correlation 0.75
- Pentose Phosphate Pathway · correlation 0.67
- Neutrophil Chemotaxis Receptors · correlation 0.63
- Myeloid Identity · correlation 0.60
- Mature Neutrophil Activation · correlation 0.41
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.