SCN4B — Sodium voltage-gated channel beta subunit 4
SCN4B belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SCN4B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Efferocytosis Anti-inflammatory Lysosomal & pahgocytosis | ABHD12, ADGRG5, AIG1, AXL, CCS, CD101, CD1D, CD300A +18 more | View in SCUBA |
| Smooth muscle cells | Calcium Handling Contractility | ASAP2, DDX24, MYCBP2, NBDY, PDE1A, RBM24, RNF180, RRAS +3 more | View in SCUBA |
About the gene
| Synonyms | LQT10 |
|---|---|
| Chromosome | 11: 118133377-118152888 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Transporters |
| Biological process | Ion transport, Sodium transport, Transport |
Function
Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels. Modulates the activity of SCN1A/Nav1.1. Modulates the activity of SCN2A/Nav1.2.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.