SEMA4A — Semaphorin 4A
SEMA4A belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SEMA4A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Heat Shock Response Stress | BCLAF1, CCNL1, CHORDC1, CLK1, FAM133B, GADD45B, HSPH1, IER5 +5 more | View in SCUBA |
| Glial cells | Integrated Stress Response Stress | ANKRD37, BAG3, CDKN1A, CSRNP1, DDIT3, EGR2, EGR3, MCL1 +3 more | View in SCUBA |
About the gene
| Synonyms | CORD10, FLJ12287, SEMAB, SemB |
|---|---|
| Chromosome | 1: 156147366-156177752 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Developmental protein |
| Biological process | Adaptive immunity, Angiogenesis, Differentiation, Immunity, Neurogenesis |
Function
Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (By similarity). Regulates glutamatergic and GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner (By similarity). Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T- helper cells, and thereby contributes to adaptive immunity (By similarity). Promotes phosphorylation of TIMD2 (By similarity). Inhibits angiogenesis (By similarity). Promotes axon growth cone collapse (By similarity). Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.