EGR2 — Early growth response 2
EGR2 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EGR2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NF-kB activation TCR/AP1/NFKb pathway | ADRA2B, CD83, CHD4, CYB5D1, DUSP2, EGR3, EGR4, FOSL1 +9 more | View in SCUBA |
| Fibroblasts | NF-κB Epigenetic Reprogramming Inflammatory | BCL3, BTG2, CDKN1A, CSRNP1, DUSP5, KDM6B, KLF10, LDLR +3 more | View in SCUBA |
| Glial cells | Integrated Stress Response Stress | ANKRD37, BAG3, CDKN1A, CSRNP1, DDIT3, EGR3, MCL1, MIDN +3 more | View in SCUBA |
| Macrophages | Early response genes Inflammatory | ATF3, BAG3, BTG2, CGAS, DNAJA1, DNAJA4, DNAJB1, DNAJB4 +39 more | View in SCUBA |
| Monocytes | Immediate-Early Inflammatory Inflammatory | CXCL2, CXCL3, CXCL8, DUSP2, EGR1, NFKBIA, NFKBIZ, OTUD1 +3 more | View in SCUBA |
| Mucosal-associated invariant T cell | NF-κB Effector Activation Inflammation | ADGRE5, BCL2A1, CCL20, CCL3, CCL3L3, CCL4, CCL4L2, DUSP10 +10 more | |
| Natural Killer cells | EGR2/3 NK Activation activation | AMD1, CHD4, CRTAM, CSF2, DNAJB9, EGR3, GADD45A, MAP2K3 +4 more | View in SCUBA |
About the gene
| Synonyms | KROX20 |
|---|---|
| Chromosome | 10: 62811996-62819167 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding, Transferase |
| Biological process | Transcription, Transcription regulation, Ubl conjugation pathway |
Function
Sequence-specific DNA-binding transcription factor. Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin (By similarity). Binds to two EGR2- consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation (By similarity). Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2 (By similarity). Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres (By similarity). Promotes the expression of HOXB3 in the rhombomere r5 in the hindbrain (By similarity). Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells (By similarity). Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons (By similarity). May play a role in adipogenesis, possibly by regulating the expression of CEBPB (By similarity). E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.