SIK2 — Salt inducible kinase 2
SIK2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SIK2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | ZEB1-driven EMT endothelial development | ASH1L, CUX1, ERBIN, ITSN2, KIF1B, MKLN1, NFAT5, NIPBL +7 more | View in SCUBA |
| Macrophages | PI3K Lipid Signaling Innate immunity | AGPAT4, AREG, DHX34, DNMBP, EEPD1, HIP1, IP6K1, IRAK2 +23 more | View in SCUBA |
About the gene
| Synonyms | DKFZp434K1115, KIAA0781, LOH11CR1I, QIK, SNF1LK2 |
|---|---|
| Chromosome | 11: 111602449-111730855 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Predicted membrane proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Function
Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism. Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity. In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL. Also plays a role in thymic T-cell development (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.