SLC1A3 — Solute carrier family 1 member 3
SLC1A3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLC1A3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Alternative Activation Lipid Lipid metabolism | ACSL1, ADCY3, AGFG1, ARHGEF10L, ARID5B, ATP2B4, BCL6, CCL13 +24 more | View in SCUBA |
| Monocytes | Efferocytosis Tissue Macrophage Lysosomal & pahgocytosis | ADORA3, AKR1B1, CPM, FCHO2, GPR34, MERTK, PDK4, STARD13 | View in SCUBA |
About the gene
| Synonyms | EA6, EAAT1, GLAST, GLAST-1, GLAST1 |
|---|---|
| Chromosome | 5: 36596588-36688334 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Amino-acid transport, Symport, Transport |
Function
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.