SLC25A33 — Solute carrier family 25 member 33
SLC25A33 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLC25A33's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | Notch TGF-β Endothelial endothelial development | ARF6, ARL4C, C16orf87, CCNL1, CLK1, DEDD2, ELOC, GPBP1 +11 more | View in SCUBA |
| Monocytes | Non-classical Monocyte State Tissue adaptation | CAMK1D, CTSC, FAM162A, MS4A7, NBDY, SLC3A2, TUBA1B, TUBB | View in SCUBA |
About the gene
| Synonyms | BMSC-MCP, MGC4399, PNC1 |
|---|---|
| Chromosome | 1: 9539465-9585173 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted membrane proteins, Transporters |
| Biological process | Transport |
Function
Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Selectively transports uridine, thymidine, guanosine, cytosine and inosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism. May import (deoxy)nucleoside triphosphates in exchange for intramitochondrial (deoxy)nucleoside diphosphates, thus providing precursors necessary for de novo synthesis of mitochondrial DNA and RNA while exporting products of their catabolism. Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration. Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production. Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.