STIM1 — Stromal interaction molecule 1
STIM1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
STIM1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | T Cell Exhaustion Exhaustion | ACADVL, ACSS1, ADSS2, B4GALT3, CDK11A, CHP1, CNOT2, CNOT8 +20 more | |
| Macrophages | Rho GTPase Signaling Cytoskeletal | ABHD18, AFF1, ARHGEF7, DIP2B, DNAAF9, DOCK11, EVI5, GNAQ +24 more | View in SCUBA |
| Mucosal-associated invariant T cell | Immune Synapse Signaling TCR Signaling | APC, ARHGAP26, ASXL2, CD46, CPSF2, DOCK8, EEA1, EIF4G3 +21 more |
About the gene
| Synonyms | D11S4896E, GOK |
|---|---|
| Chromosome | 11: 3854527-4093210 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Calcium transport, Ion transport, Transport |
Function
Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release- activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)- selective (ARC) channels. Plays a role in mediating store- operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry. Involved in enamel formation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.