TMEM203 — Transmembrane protein 203
TMEM203 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TMEM203's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | TCR Vesicular Trafficking TCR Signaling | ARL2BP, ARL8A, ARRDC1, C18orf32, CCDC92, CD3D, CD3G, CD99 +14 more | |
| Mucosal-associated invariant T cell | Cytotoxic Effector cytotoxicity | ANXA4, CCM2, CD320, CST7, DYNLRB1, GZMM, LIMD2, MCUB +10 more |
About the gene
| Synonyms | HBEBP1, MGC14327 |
|---|---|
| Chromosome | 9: 137204082-137205648 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
Function
Involved in the regulation of cellular calcium homeotasis. Required for spermatogenesis. Acts as a regulator of STING-mediated inflammatory signaling in macrophages. Forms a complex with STING, promoting the activity of TBK1 kinase and the transcription factor IRF3, leading to activation of type I interferon expression (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.