VPS13D — Vacuolar protein sorting 13 homolog D
VPS13D belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
VPS13D's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Endosomal Vesicle Trafficking Vesicular traficking | ADAM17, AP3B1, ARFGEF1, ARID1B, ARK2N, ASAP1, ATF6, ATP11A +48 more | View in SCUBA |
| Smooth muscle cells | SMC Phenotype Regulation Development | ARHGAP42, BMPR2, CTXN1, EFR3A, FAM20B, HACD4, INPP5A, OSBPL1A +5 more | View in SCUBA |
About the gene
| Synonyms | BLTP5D, FLJ10619, KIAA0453 |
|---|---|
| Chromosome | 1: 12230030-12512047 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Predicted intracellular proteins |
| Biological process | Lipid transport, Transport |
Function
Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission. Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.