SCUBA

PFDN2 — Prefoldin subunit 2

PFDN2 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PFDN2's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsChaperonin Protein Folding
Protein processing & ER
BANF1, CCT2, CCT3, CCT4, CCT5, CCT6A, EIF2S1, ILF2 +5 moreView in SCUBA
CD4⁺ T cellsT cell activation
TCR/AP1/NFKb pathway
ANKS1B, ARF6, CCT6A, EHD4, HNRNPM, IRF4, MAP2K3, TRIB1 +3 moreView in SCUBA
EndothelialActin Cytoskeletal Remodeling
Cytoskeletal
ACTB, ACTG1, ARF1, ARPC5L, CFL1, CYCS, DNAJB11, DNAJC1 +5 moreView in SCUBA
FibroblastsHypoxia Response
Stress
ACSL4, AP2S1, ARFGAP3, C4orf48, EPAS1, HIF1A, IL4R, ISG20 +8 moreView in SCUBA
Gamma-delta T cellsTranscriptional Repressor Complex
DNA/chromatin regulation
BAG1, CAB39, CLEC2B, EBP, FBXO31, GFI1, MAN1A1, MAP2K1 +14 more
Goblet cellsProteostasis Housekeeping
Housekeeping
ADRM1, EIF2S2, GNB2, MAGOHB, NME1, NUDC, OAZ1, PARK7 +4 moreView in SCUBA
Innate lymphoid cellsMitochondrial Translation
Mitochondrial & OxPhos
ABCF1, ARGLU1, ATG12, BAG1, C1orf35, CHCHD1, CHMP5, DNAJC7 +37 moreView in SCUBA
Lymphatic endothelialOxidative Stress Response
Stress
ANXA5, ATP6V0B, CCT3, CD59, DRAP1, EIF5A, GPX4, NUPR1 +3 moreView in SCUBA
MacrophagesProteasome UPS
Housekeeping
ATP6V1D, ATP6V1E1, BAX, C1orf43, COX7A2L, DCUN1D5, DNAJC15, DNAJC8 +28 moreView in SCUBA

About the gene

Chromosome1: 161100556-161118055
Predicted locationIntracellular
Essential geneYes
Protein classEssential proteins, Plasma proteins, Predicted intracellular proteins
Molecular functionChaperone

Function

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.