SCUBA

NDUFB3 — NADH:ubiquinone oxidoreductase subunit B3

NDUFB3 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

NDUFB3's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsOxidative Phosphorylation
Mitochondrial & OxPhos
ATP5MC3, ATP5MF, ATP5PB, ATP5PF, COX5A, ELOB, ERH, LDHB +8 moreView in SCUBA
CD4⁺ T cellsOxidative Phosphorylation
Mitochondrial & OxPhos
AP2S1, ATP5F1C, ATP5PF, COPS9, COX6B1, EID1, FAM89B, FDPS +19 moreView in SCUBA
CD8⁺ T cellsComplex I / OXPHOS
Mitochondrial & OxPhos
DAD1, GSTO1, GTF3C6, MANF, NDUFA12, NDUFA4, NDUFAB1, NDUFS6 +1 moreView in SCUBA
EndothelialMitochondrial OxPhos
Mitochondrial & OxPhos
ARPC3, CLTB, COX6A1, COX7A2, COX7B, DAD1, ELOB, MYL12B +9 moreView in SCUBA
EnterocytesElectron Transport Chain
Mitochondrial & OxPhos
ATP5MG, ATP5MJ, ATP5PD, ATP5PO, COX5B, COX6B1, COX7B, COX7C +6 moreView in SCUBA
Gamma-delta T cellsComplex I Assembly
Mitochondrial & OxPhos
AKR7A2, AP2S1, BLOC1S1, DCTN2, HSD17B10, LAMTOR2, MGMT, MRPL34 +13 more
Innate lymphoid cellsProteasome ER Proteostasis
Protein processing & ER
ATP5MC1, ATP5PF, DBI, GNG5, GTF3C6, HNRNPK, IL4I1, MANF +19 moreView in SCUBA
MacrophagesATP Synthase Complex
Mitochondrial & OxPhos
ATP5MJ, ATP5MK, ATP5PF, COX7A2, COX7B, GTF2A2, GTF3C6, LSM6 +14 moreView in SCUBA
Mucosal-associated invariant T cellMitochondrial Biogenesis
Mitochondrial & OxPhos
ARFRP1, ARL2, ATP6V0E1, CALHM2, CCS, COA4, DBP, DENND2D +15 more

About the gene

SynonymsB12
Chromosome2: 201071433-201085750
Predicted locationMembrane
Essential geneYes
Protein classDisease related genes, Essential proteins, Human disease related genes, Metabolic proteins, Predicted membrane proteins
Biological processElectron transport, Respiratory chain, Transport

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.