PPIF — Peptidylprolyl isomerase F
PPIF belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PPIF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | mRNA splicing factors RNA processing | CALM1, CALM2, CKS2, CYCS, EIF4A3, HNRNPA0, HNRNPA2B1, HNRNPAB +12 more | View in SCUBA |
| CD4⁺ T cells | Effector activation NFkB TCR/AP1/NFKb pathway | ADAM19, AHR, ARFGAP3, ATF5, BHLHE40, CGAS, DUSP5, ETF1 +23 more | View in SCUBA |
| Fibroblasts | Proteotoxic Stress Survival Stress | ARL5B, BAG3, DNAJA4, ICAM1, PPP1R15B, SLC25A25, TIPARP, TNFRSF10D | View in SCUBA |
| Gamma-delta T cells | G1/S Entry Cell cycle | CDKN2A, CKS2, CMC2, H2AZ1, H2AZ2, HMGB2, IFI27L1, KPNA2 +15 more | |
| Innate lymphoid cells | Cytokine-driven Activation activation | BIRC3, CALR, CD69, DUSP5, GADD45G, ISG15, NCOA7, RUNX3 +2 more | View in SCUBA |
| Macrophages | Lipid-Sensing Transcriptional Lipid metabolism | ANKLE2, BAIAP2, C19orf25, C1orf52, COX19, CWC25, DEDD2, DNTTIP2 +29 more | View in SCUBA |
| Monocytes | Epigenetic Inflammatory Reprogramming Inflammatory | BHLHE40, EHD1, KDM6B, PHACTR1, PLEK, SMAD7, SOD2, ZNF267 | View in SCUBA |
About the gene
| Synonyms | Cyp-D, CypD, hCyP3 |
|---|---|
| Chromosome | 10: 79347469-79355334 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters |
| Molecular function | Isomerase, Rotamase |
| Biological process | Apoptosis, Necrosis |
Function
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (By similarity). Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.