PHKB — Phosphorylase kinase regulatory subunit beta
PHKB belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PHKB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin & genome maintenance DNA/chromatin regulation | ARID1B, ASH1L, ATM, ATRX, BOD1L1, DDX17, KANSL1, MARF1 +8 more | View in SCUBA |
| CD4⁺ T cells | Inflammatory effector Immune regulation | C3AR1, CAST, CLDND1, CMTM3, CREB3L2, EIF4E3, EPB41, FYCO1 +9 more | View in SCUBA |
| Gamma-delta T cells | Immune Negative Regulation Immune regulation | ATAD1, CABIN1, DGLUCY, FYB1, GMIP, ICE2, KMT5B, NFX1 +4 more | |
| Lymphatic endothelial | Chromatin Remodeling DNA/chromatin regulation | BAZ2B, CHD9, ITFG1, JMJD1C, MICAL3, MPDZ, PACSIN2, PLXDC2 +4 more | View in SCUBA |
| Macrophages | Post-transcriptional Regulation Housekeeping | AKAP10, ATF7IP, ATRN, ATXN2, BAZ2B, BLTP1, BRWD1, CELF2 +34 more | View in SCUBA |
About the gene
| Chromosome | 16: 47461123-47701523 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Calmodulin-binding |
| Biological process | Carbohydrate metabolism, Glycogen metabolism |
Function
Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.