KMT2C — Lysine methyltransferase 2C
KMT2C belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KMT2C's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin modifiers DNA/chromatin regulation | ATP2A3, BIRC6, KDM5A, LPIN1, MBNL1, NCOA3, NFAT5, RBM5 +1 more | View in SCUBA |
| CD4⁺ T cells | DNA repair/replication DNA/chromatin regulation | ACAP2, BROX, CCDC88C, CKAP2, EPM2AIP1, FOXO3, HAUS3, HELB +4 more | View in SCUBA |
| Gamma-delta T cells | Chromatin Epigenetic Regulation DNA/chromatin regulation | ACIN1, ASH1L, BDP1, BLTP1, CLTC, EPS15, EXOC2, FAM120B +24 more | |
| Lymphatic endothelial | Chromatin Remodeling DNA/chromatin regulation | DYRK1A, HERC1, KDM6A, MBNL1, MED13L, MRTFA, NCOA1, PDE8A +2 more | View in SCUBA |
| Macrophages | Epigenetic Remodeling Housekeeping | AFF4, AGO3, AKAP13, ARID4B, ASH1L, CYTH1, ELF1, EPC1 +16 more | View in SCUBA |
| Mucosal-associated invariant T cell | Calcium Signal Integration TCR Signaling | ANKRD44, ARB2A, CAMK2D, DOCK10, ELMO1, EXOC4, FCHSD2, FNDC3A +20 more | |
| Neutrophils | ELMO-DOCK Chemotaxis Chemotaxis | BCAS3, CDK19, DOCK2, ELMO1, NCOA2, STAG1, VPS13B |
About the gene
| Synonyms | HALR, KIAA1506, MLL3 |
|---|---|
| Chromosome | 7: 152134922-152436644 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Activator, Acyltransferase, Chromatin regulator, DNA-binding, Methyltransferase, Transferase |
| Biological process | Transcription, Transcription regulation |
Function
Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place. Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.