BIRC6 — Baculoviral IAP repeat containing 6
BIRC6 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BIRC6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin modifiers DNA/chromatin regulation | ATP2A3, KDM5A, KMT2C, LPIN1, MBNL1, NCOA3, NFAT5, RBM5 +1 more | View in SCUBA |
| CD4⁺ T cells | Chromatin regulation DNA/chromatin regulation | ANKRD11, CNTRL, EP300, FAM118A, GOLGA4, IRF2, KAT6A, MIER1 +12 more | View in SCUBA |
| Lymphatic endothelial | Focal Adhesion Migration migration & adhesion | CDC42BPA, DOCK1, EIF4G3, GNAQ, LPP, NF1, PAM, PTK2 +2 more | View in SCUBA |
| Macrophages | Rho GTPase Signaling Cytoskeletal | ABCC1, ABR, ANKRD17, ARFGEF2, ARHGAP10, ARID2, ATAD2B, ATP9B +44 more | View in SCUBA |
| Mucosal-associated invariant T cell | Lymphocyte Migration migration & adhesion | AP3B1, ATP9B, BTBD9, CEP350, DOCK11, DOCK2, ERBIN, FRYL +8 more |
About the gene
| Synonyms | BRUCE |
|---|---|
| Chromosome | 2: 32357023-32619571 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Protease inhibitor, Thiol protease inhibitor, Transferase |
| Biological process | Apoptosis, Cell cycle, Cell division, Mitosis, Ubl conjugation pathway |
Function
Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase. Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide. Ubiquitination is mediated by a non- canonical E1 ubiquitin activating enzyme UBA6. Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent. Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2. DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases. Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.