RBM5 — RNA binding motif protein 5
RBM5 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RBM5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin modifiers DNA/chromatin regulation | ATP2A3, BIRC6, KDM5A, KMT2C, LPIN1, MBNL1, NCOA3, NFAT5 +1 more | View in SCUBA |
| CD4⁺ T cells | T-cell costimulation TCR/AP1/NFKb pathway | ASH1L, BOD1L1, CCM2, CCR4, CD28, CREBRF, DDX27, ERBIN +10 more | View in SCUBA |
| Gamma-delta T cells | T Cell Maturation T cell maturation | CDK13, CWF19L2, EMB, EZH1, ICE1, IKZF1, JAK1, KLF13 +16 more | |
| Innate lymphoid cells | Splicing & Transcription RNA processing & translation | ACTR2, BDP1, CDC5L, CYLD, DHX36, FXR1, GPATCH2, MTPN +12 more | View in SCUBA |
| Macrophages | Pre-mRNA Splicing Housekeeping | AAK1, ANKRD12, ANKRD13D, ARGLU1, BRD2, C3orf62, CREBZF, DMTF1 +20 more | View in SCUBA |
About the gene
| Synonyms | H37, LUCA-15, LUCA15 |
|---|---|
| Chromosome | 3: 50088919-50119021 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | RNA-binding |
| Biological process | Apoptosis, mRNA processing, mRNA splicing |
Function
Component of the spliceosome A complex. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3'. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.