TCF4 — Transcription factor 4

TCF4 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

TCF4's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	B cell activation B cell maturation	CCDC50, IL10RA, NCR3, PTPN12, RBM47, RORA, SAMSN1, TBC1D9 +4 more	View in SCUBA
Hematopoietic progenitor cells	Lymphoid Progenitor TFs Lymphcyte development	ADAM28, AFF3, ANKRD44, CYFIP2, CYLD, HLA-DMB, MEF2C, PDE7A +4 more
Macrophages	ER Stress Response Stress	ARHGEF12, ATXN7, BTBD7, CD2AP, CLIP2, DAPK1, DST, ERN1 +14 more	View in SCUBA
Pericytes	TGF-beta Negative Feedback Inflammatory	CTNND1, DAZAP2, EMP1, KAT6A, KBTBD2, KLF7, MLKL, RCAN1 +6 more	View in SCUBA
Smooth muscle cells	STAT3 transcriptional program Activation	DDX3X, FAM210B, HLA-E, HNRNPH1, ID4, ITPR1, NOLC1, RAB21 +2 more	View in SCUBA

About the gene

Synonyms	bHLHb19, E2-2, ITF2, SEF2-1B
Chromosome	18: 55222185-55664787
Predicted location	Intracellular, Secreted
Essential gene	No
Protein class	Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins, Transcription factors
Molecular function	Activator, DNA-binding
Biological process	Differentiation, Neurogenesis, Transcription, Transcription regulation

Function

Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'- CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'- CCANNTGG-3'

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.