PSMD11 — Proteasome 26S subunit, non-ATPase 11

PSMD11 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PSMD11's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Proteasome/translation Protein processing & ER	ANP32E, CDC123, EIF4E, EIF5B, EMC8, MRPL20, NME7, PDXK +9 more	View in SCUBA
Innate lymphoid cells	Innate Immune Activation Inflammation	ANKRD11, ATP10D, CNOT2, COA4, DOCK10, IKZF2, NIFK, PRKDC +13 more	View in SCUBA
Lymphatic endothelial	NRF2 Oxidative Stress Stress	B4GALT1, CTTNBP2NL, DDX21, DRAM1, GCH1, HNRNPF, MSN, NFE2L2 +11 more	View in SCUBA
Macrophages	Osmotic Stress Response Stress	ANKRD28, BZW1, CD109, CXCL8, CYB5R4, CYTIP, DUSP4, EMP3 +25 more	View in SCUBA

About the gene

Synonyms	MGC3844, p44.5, Rpn6, S9
Chromosome	17: 32444379-32483319
Predicted location	Intracellular
Essential gene	Yes
Protein class	Essential proteins, Plasma proteins, Predicted intracellular proteins

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.