T cell activation
Gene co-expression module in CD4⁺ T cells
| Category | TCR/AP1/NFKb pathway |
|---|---|
| Genes | 12 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 12 genes have a known function matching the annotation |
Why this annotation
This module is distinct from its OxPhos neighbors. Hubs include chaperonin/prefoldin (CCT6A, PFDN2), RNA/DNA-binding factors (HNRNPM, XRCC5, ZNF706), and notably signaling/activation genes TRIB1, MAP2K3, IRF4, ARF6, YWHAE. IRF4 is a key transcription factor for CD4 T effector/Th differentiation, TRIB1 and MAP2K3 are stress/MAPK-linked, suggesting an activation-associated program. The signature is strongly inflammation-associated (high delta_inflammation in both UC and CD) and reverses with treatment. The mix of protein-folding and activation signaling suggests a proliferating/activated T cell biosynthetic state rather than a clean single pathway. IRF4/TRIB1/MAP2K3 point toward T cell activation programs.
Genes
ANKS1B, ARF6, CCT6A, EHD4, HNRNPM, IRF4, MAP2K3, PFDN2, TRIB1, XRCC5, YWHAE, ZNF706
Most correlated modules
- OxPhos & redox · correlation 0.86
- Oxidative Phosphorylation · correlation 0.83
- Regulatory T cell · correlation 0.83
- Protein/ER secretory machinery · correlation 0.82
- CCR5 effector migration · correlation 0.82
- Lipid Metabolism · correlation 0.82
- Mitochondrial Translation · correlation 0.81
- OxPhos & proteasome · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.