IFN-gamma Stress Response
Gene co-expression module in CD8⁺ T cells
| Category | Inflammation |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
Top hubs: MT2A and MT1E are metallothioneins (metal stress/antioxidant response); PSMB9 (immunoproteasome beta subunit, IFN-gamma inducible), PSME2 (proteasome activator, IFN-gamma inducible); FABP5 (fatty acid binding, metabolic/stress), COX5B (mitochondrial), PHPT1, VOPP1, SUB1. The co-occurrence of metallothioneins with immunoproteasome components suggests an interferon/oxidative stress response program. MT2A/MT1E are induced by oxidative and heavy metal stress; PSMB9/PSME2 are canonical IFN-gamma response genes. FABP5 is associated with lipid metabolism in activated T cells. This module likely reflects an interferon-gamma-driven immunoproteasome activation combined with metal/oxidative stress responses — possibly a stress-inflammatory hybrid.
Genes
COX5B, FABP5, MT1E, MT2A, PHPT1, PSMB9, PSME2, SUB1, VOPP1
Most correlated modules
- Mitochondrial OxPhos · correlation 0.94
- RNA Splicing Complex · correlation 0.94
- Cellular Housekeeping · correlation 0.93
- Proteasome Degradation · correlation 0.93
- ER-Golgi Trafficking · correlation 0.92
- Mitochondrial ETC/OxPhos · correlation 0.92
- Glycolysis Program · correlation 0.91
- MHC Class II Presentation · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.