GZMA — Granzyme A
GZMA belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GZMA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic effector Cytotoxicity | ADAP1, ALOX5AP, AOAH, CD244, CMIP, CPNE7, CRTAM, DAPK2 +15 more | View in SCUBA |
| CD8⁺ T cells | Cytotoxic Gut Effector cytotoxicity | ATP8B4, CCND2, CD63, CEBPB, CSF1, CTSA, GNLY, GNPTAB +3 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cellular Housekeeping Housekeeping | AKR7A2, ANP32A, ANXA5, AP1M1, APEX1, APOBEC3C, CDC26, DBNL +17 more | |
| Natural Killer cells | NK Cytotoxic Activation Cytotoxicity | ABI3, ALOX5AP, ARHGDIB, BPGM, CD247, GNPTAB, HCLS1, LAT2 +3 more | View in SCUBA |
About the gene
| Synonyms | CTLA3, HFSP |
|---|---|
| Chromosome | 5: 55102646-55110252 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Enzymes, Predicted secreted proteins |
| Molecular function | Hydrolase, Protease, Serine protease |
| Biological process | Cytolysis |
Function
Abundant protease in the cytosolic granules of cytotoxic T- cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-B (GSDMB), releasing the pore-forming moiety of GSDMB, thereby triggering pyroptosis and target cell death. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.