IL2RB — Interleukin 2 receptor subunit beta
IL2RB belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IL2RB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Activated effector Tcell Immune regulation | APOBEC3C, ARPP19, CISD2, CTSC, ENTPD1, GLUD1, LYST, MICAL2 +4 more | View in SCUBA |
| CD8⁺ T cells | Cytotoxic Gut Effector cytotoxicity | ATP8B4, CCND2, CD63, CEBPB, CSF1, CTSA, GNLY, GNPTAB +3 more | View in SCUBA |
| Gamma-delta T cells | NK/T Cell Identity T cell maturation | AFTPH, ARHGAP17, ASXL2, ATF7IP, CALCOCO2, CD244, CLK3, GDI1 +24 more | |
| Innate lymphoid cells | Antigen Processing MHC-I Immune regulation | CMTM6, GUK1, IL4R, MYL12A, PAXX, PSMA5, PSMB8, PSMB9 +8 more | View in SCUBA |
About the gene
| Synonyms | CD122, IL15RB |
|---|---|
| Chromosome | 22: 37118666-37175118 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Transporters |
| Molecular function | Receptor |
| Biological process | Host-virus interaction |
Function
Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.