Effector Memory CD8
Gene co-expression module in CD8⁺ T cells
| Category | T cell maturation |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
The module contains KLRG1 (marker of terminally differentiated/short-lived effector CD8 T cells), GZMK (granzyme K, expressed in effector memory CD8 T cells), GIMAP7, GIMAP4, GIMAP1 (GTPases essential for T cell survival and differentiation, enriched in peripheral effector T cells), GPR183 (EBI2, chemokine receptor expressed on effector/memory T cells), PLEK (pleckstrin, expressed in activated lymphocytes/NK cells), CLDND1 (claudin domain protein in lymphocytes), TC2N (expressed in lymphocytes), LYAR (lymphocyte-specific nuclear protein), DENND2D (expressed in immune cells), ITM2C. KLRG1 + GZMK + GIMAP family together define a mature effector memory CD8 T cell program. This is consistent with a circulating or gut-resident effector memory state prior to terminal exhaustion.
Genes
CLDND1, DENND2D, GIMAP1, GIMAP4, GIMAP7, GPR183, GZMK, ITM2C, KLRG1, LYAR, PLEK, TC2N
Most correlated modules
- Effector-Memory CD8 · correlation 0.56
- AP-1 Early Activation · correlation 0.55
- Naive/Central Memory · correlation 0.54
- Naive/Memory CD8 · correlation 0.46
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.