COPRS — Coordinator of PRMT5 and differentiation stimulator
COPRS belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COPRS's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Nucleotide biosynthesis Housekeeping | CCT7, DCTPP1, MRPL12, MRPL4, NHP2, NME1, PPA1, PRDX4 +6 more | View in SCUBA |
| CD8⁺ T cells | RNA & Redox Housekeeping RNA processing & translation | ANP32A, C11orf58, CCT6A, DPM2, GGCT, GLRX3, LAGE3, NME1 +3 more | View in SCUBA |
| Endothelial | NF-κB Oxidative Stress Stress | ACP1, ALDH7A1, ARHGDIB, CCDC85C, CDC25B, CDKN3, CMSS1, CYTL1 +13 more | View in SCUBA |
| Lymphatic endothelial | RNA Protein Homeostasis RNA processing & translation | ADRM1, BAG1, ILF2, RAB32, RAN, RBM8A, SLC25A5, SNRPB +2 more | View in SCUBA |
About the gene
| Synonyms | C17orf79, COPR5, HSA272196, TTP1 |
|---|---|
| Chromosome | 17: 31851871-31859291 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Chromatin regulator |
| Biological process | Myogenesis, Transcription, Transcription regulation |
Function
Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.