RMI2 — RecQ mediated genome instability 2
RMI2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RMI2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Histone Synthesis S-phase Cell cycle | CDK2, EIF4EBP1, HAT1, HNRNPF, HPRT1, PAQR4, SLBP, TMEM109 | View in SCUBA |
| Hematopoietic progenitor cells | DNA Replication S-phase Cell cycle | CDT1, CENPH, CENPK, CHEK1, E2F1, FEN1, GINS2, GMNN +4 more |
About the gene
| Synonyms | BLAP18, C16orf75, MGC24665 |
|---|---|
| Chromosome | 16: 11249619-11381662 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | DNA replication |
Function
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.