EIF4EBP1 — Eukaryotic translation initiation factor 4E binding protein 1
EIF4EBP1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EIF4EBP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Histone Synthesis S-phase Cell cycle | CDK2, HAT1, HNRNPF, HPRT1, PAQR4, RMI2, SLBP, TMEM109 | View in SCUBA |
| Endothelial | Redox Stress Response Stress | APEX1, ATP5F1E, ATP5MC1, CDC42EP5, EPS8L1, MAGED1, MCFD2, MRPL12 +7 more | View in SCUBA |
| Hematopoietic progenitor cells | Nucleotide Metabolism Housekeeping | DCTPP1, DNPH1, FKBP4, GCSH, METTL26, MRPL12, NHP2, NME4 +2 more | |
| Macrophages | Oxidative Metabolic Program Mitochondrial & OxPhos | ACADM, CA2, CALM3, CAPG, COQ2, CSRP1, CSTB, DENND2D +29 more | View in SCUBA |
About the gene
| Synonyms | 4E-BP1, PHAS-I |
|---|---|
| Chromosome | 8: 38030534-38060365 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted intracellular proteins |
| Molecular function | Protein synthesis inhibitor |
| Biological process | Translation regulation |
Function
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.