NUDT5 — Nudix hydrolase 5
NUDT5 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NUDT5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Interferon-stimulated genes Anti-viral | APOBEC3G, ARPC4, ARPC5L, BAK1, BST2, DCTN3, ECH1, ETFB +14 more | View in SCUBA |
| CD8⁺ T cells | Cellular Housekeeping Housekeeping | CDC123, CHCHD2, COX5A, MRPL52, PDIA6, PSMB6, PSMC1, RBX1 +3 more | View in SCUBA |
| Endothelial | Proteasomal Degradation Protein processing & ER | GNL3, HACD3, MRPL36, NME4, PON2, PSMA1, PSMB5, PSMC1 +3 more | View in SCUBA |
| Gamma-delta T cells | Mitoribosome Small Subunit Mitochondrial & OxPhos | ACADM, C14orf119, CHCHD1, COA3, COA4, COMMD8, GALK1, GEMIN6 +24 more | |
| Macrophages | Replication Chromatin Assembly Cell cycle | ANP32B, CBX3, CDK4, COPS3, DEK, DNMT1, EMC8, EXOSC8 +22 more | View in SCUBA |
| Neutrophils | Immature Granulocyte Progenitor Developmental | ACSL4, AMPH, AVIL, CDC123, ENSG00000282804, HAL, HRH2, MAOA +3 more |
About the gene
| Synonyms | hYSAH1, YSA1H |
|---|---|
| Chromosome | 10: 12165330-12196144 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, RNA-binding, Transferase |
Function
Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.