UBE2I — Ubiquitin conjugating enzyme E2 I
UBE2I belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UBE2I's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Cellular Housekeeping Housekeeping | CDC123, CHCHD2, COX5A, MRPL52, NUDT5, PDIA6, PSMB6, PSMC1 +3 more | View in SCUBA |
| Endothelial | Housekeeping Metabolic Housekeeping | ANXA5, ATP5MC3, CCT5, COX6B1, CTSL, DCTPP1, ERH, GSTO1 +8 more | View in SCUBA |
| Goblet cells | RNA Decay Processing RNA processing & translation | CCNI, ILF2, RBPJ, RSL24D1, SRSF3, SYNCRIP, UBE2R2, XRCC5 +2 more | View in SCUBA |
| Innate lymphoid cells | Mitochondrial Translation Mitochondrial & OxPhos | ABCF1, ARGLU1, ATG12, BAG1, C1orf35, CHCHD1, CHMP5, DNAJC7 +37 more | View in SCUBA |
| Macrophages | Protein Biogenesis Housekeeping | ATP6V0D1, B3GAT3, BUD23, C11orf58, CHD4, CNPY2, DAZAP1, DDX46 +23 more | View in SCUBA |
About the gene
| Synonyms | UBC9 |
|---|---|
| Chromosome | 16: 1308880-1327018 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Essential proteins, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters |
| Molecular function | Transferase |
| Biological process | Cell cycle, Cell division, Chromosome partition, Host-virus interaction, Mitosis, Ubl conjugation pathway |
Function
Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. Mediates sumoylation of ERCC6 which is essential for its transcription-coupled nucleotide excision repair activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.