PHPT1 — Phosphohistidine phosphatase 1

PHPT1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PHPT1's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Interferon Response Anti-viral	APOL6, ARL6IP5, BAX, GBP4, GBP5, IFI16, IQGAP1, IRF9 +4 more	View in SCUBA
CD8⁺ T cells	IFN-gamma Stress Response Inflammation	COX5B, FABP5, MT1E, MT2A, PSMB9, PSME2, SUB1, VOPP1	View in SCUBA
Endothelial	Mitochondrial Oxidative Stress Stress	AGTRAP, AP2M1, ECHS1, ECSCR, EDF1, EIF5A, NEDD8, PARK7 +5 more	View in SCUBA
Gamma-delta T cells	Mitochondrial OxPhos Mitochondrial & OxPhos	ADSL, AP1S1, CD151, COMTD1, COX5A, DDT, DNPH1, DUSP23 +20 more
Glial cells	Glial Neuroprotective Response Neroprotection	ANXA4, CYB5A, DPYSL3, DRAP1, FADS2, IGFBP4, MDK, NBDY +4 more	View in SCUBA
Innate lymphoid cells	ILC-1 identity Differentiation	ABRACL, BLOC1S1, C19orf53, CD52, DAD1, FUCA2, GMFG, HMGN3 +20 more	View in SCUBA
Macrophages	Glycolytic Metabolism Housekeeping	ARL1, ARPC5, ATP5PB, ATRAID, C4orf3, CALM1, CAPZA2, CHMP5 +30 more	View in SCUBA
Mucosal-associated invariant T cell	Mitochondrial Ribosome Mitochondrial & OxPhos	AGTRAP, BRK1, C11orf68, C14orf119, CNPY2, CZIB, DCTPP1, DYNC1I2 +22 more

About the gene

Synonyms	bA216L13.10, CGI-202, DKFZp564M173, HSPC141, PHP14
Chromosome	9: 136848724-136851027
Predicted location	Intracellular
Essential gene	No
Protein class	Enzymes, Metabolic proteins, Predicted intracellular proteins
Molecular function	Hydrolase, Protein phosphatase

Function

Exhibits phosphohistidine phosphatase activity

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.