ILC/NK Development
Gene co-expression module in Hematopoietic progenitor cells
| Category | Lymphcyte development |
|---|---|
| Genes | 16 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 16 genes have a known function matching the annotation |
Why this annotation
ID2 is the master TF for ILC and NK cell development; NFIL3 (E4BP4) is essential for NK and ILC differentiation; RUNX3 drives NK/ILC and cytotoxic T programs; ITGB7 (integrin beta-7) marks gut-homing lymphocytes including ILCs; CD3E marks T/ILC precursors; NFATC4 is active in T/NK cells; CYSLTR1 is a hallmark marker of ILC2; ADGRD1 is expressed in lymphoid cells. The core coherence and hub gene constellation strongly support an ILC/NK developmental program among HPCs, consistent with the broader lymphocyte neighborhood (M30, M70).
Genes
ACY3, ADGRD1, ATP10A, CCDC141, CD3E, CYSLTR1, ID2, ITGB7, NFATC4, NFIL3, NYNRIN, RUNX3, SCPEP1, SEMA4D, SYT2, TTN
Most correlated modules
- ILC3/γδT Priming · correlation 0.87
- Lymphocyte Signaling · correlation 0.87
- Dendritic Cell Progenitor · correlation 0.86
- Myeloid Innate Immune · correlation 0.82
- Regulatory T-cell State · correlation 0.76
- MHC-I Antigen Presentation · correlation 0.68
- T/NK Cell Identity · correlation 0.66
- Lymphoid Progenitor TFs · correlation 0.53
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.