NFIL3 — Nuclear factor, interleukin 3 regulated

NFIL3 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

NFIL3's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Th17 effector Th17 fate	CD6, CLSTN3, CTDSP1, IL17A, ITPRIPL2, MAP3K4, MPRIP, NMRK1 +6 more	View in SCUBA
Fibroblasts	NF-κB Stress Response Inflammatory	EGR3, NAMPT, NCOA7, PHLDA1, PHLDA2, SAT1, SLC20A1, SOD2 +3 more	View in SCUBA
Gamma-delta T cells	T Cell Exhaustion Exhaustion	AKAP5, AOAH, CCDC141, CD8A, CD8B, CDYL, CRTAM, CYSTM1 +20 more
Hematopoietic progenitor cells	ILC/NK Development Lymphcyte development	ACY3, ADGRD1, ATP10A, CCDC141, CD3E, CYSLTR1, ID2, ITGB7 +7 more
Innate lymphoid cells	AP-1 Transcriptional Activation DNA regulation & transcription	AHNAK, ALYREF, CD81, CDV3, CITED4, ESYT2, ETS1, GNAI2 +28 more	View in SCUBA
Lymphatic endothelial	NF-κB Negative Feedback Inflammation	BMP2, C2CD4B, ICAM1, IRF8, KLF6, MAFF, NFKBIA, PRNP +4 more	View in SCUBA
Macrophages	Autophagy Vesicle Trafficking Lysosomal & pahgocytosis	ADNP2, AGO2, AP1G1, ARFGAP3, ATG2A, BANP, CHD1, CHD2 +26 more	View in SCUBA
Smooth muscle cells	IFN-gamma/NF-kB Response Inflammation	ATP6V0B, CCDC71L, CFLAR, CHI3L2, EVA1B, GBP1, GBP2, HSPA8 +11 more	View in SCUBA

About the gene

Synonyms	E4BP4, IL3BP1, NF-IL3A, NFIL3A
Chromosome	9: 91409045-91423832
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins, Transcription factors
Molecular function	Activator, DNA-binding, Repressor
Biological process	Biological rhythms, Transcription, Transcription regulation

Function

Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity). Represses the transcription of CYP2A5 (By similarity). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (By similarity). Required for the development of natural killer cell precursors (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.