RTN3 — Reticulon 3
RTN3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RTN3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Replication Licensing Cell cycle | ACYP1, DDB2, DSN1, GMNN, HIRIP3, ITGB3BP, LSM3, MAGOHB +8 more | View in SCUBA |
| Hematopoietic progenitor cells | Erythro-Megakaryocytic Development Erythropoietic | CAMLG, HACD1, ICAM4, IL1B, LYL1, MPP1, NFE2, NT5M +1 more | |
| Macrophages | ER Membrane Homeostasis Housekeeping | ATP6V1A, BNIP2, CANX, CAPZA1, CD164, CMTM6, COPB1, EXOC5 +18 more | View in SCUBA |
| Neutrophils | Degranulation Trafficking Degranulation | ATP11A, BIN2, CSGALNACT2, FRY, KDM7A, LPGAT1, PYGL, RAB27A +7 more |
About the gene
| Synonyms | ASYIP, HAP, NSPL2, NSPLII, RTN3-A1 |
|---|---|
| Chromosome | 11: 63681446-63759891 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Apoptosis, ER-Golgi transport, Host-virus interaction, Stress response, Transport |
Function
May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules. Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.