PIK3AP1 — Phosphoinositide-3-kinase adaptor protein 1
PIK3AP1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PIK3AP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | T cell Identity Signaling TCR Signaling | CDC42SE1, CLIP4, ETS1, FCHSD1, H3C1, ITGA4, ITK, KHNYN +14 more | |
| Hematopoietic progenitor cells | Lymphocyte Signaling Lymphcyte development | ADGRG5, AHR, AKNA, CARD11, CORO1A, CYTH4, KIAA0930, LSP1 +3 more | |
| Macrophages | Myeloid Differentiation Identity Developmental | ADCK2, ALOX5, ATP2C1, CCDC6, CDK6, CMTM7, DEF6, EEF2K +21 more | View in SCUBA |
| Monocytes | Inflammasome Activation Innate immunity | AIM2, APOBEC3G, ARID5B, BATF3, BST2, CASP5, CD47, CNDP2 +4 more | View in SCUBA |
| Mucosal-associated invariant T cell | Splicing Regulation RNA processing & translation | AREG, ARHGAP9, AZIN1, CCNH, CLK1, DDX24, DNAJB6, IL23R +9 more |
About the gene
| Synonyms | BCAP, FLJ35564 |
|---|---|
| Chromosome | 10: 96593315-96720514 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3- kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll- like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.