SYNCRIP — Synaptotagmin binding cytoplasmic RNA interacting protein
SYNCRIP belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SYNCRIP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Epigenetic regulation DNA/chromatin regulation | AFF4, ARID1B, CTSA, DGKH, FUBP1, JARID2, PDCD6, TET2 +6 more | View in SCUBA |
| Endothelial | ER-Golgi Trafficking Protein processing & ER | ARPC1A, CCT8, FIBP, GDI2, GGCT, LMAN2, MAP2K2, MRPS16 +10 more | View in SCUBA |
| Gamma-delta T cells | DNA Damage Response DNA/chromatin regulation | AP1B1, CCAR1, CHD8, DOCK2, EP400, ERBIN, GOLM2, IPO8 +17 more | |
| Goblet cells | RNA Decay Processing RNA processing & translation | CCNI, ILF2, RBPJ, RSL24D1, SRSF3, UBE2I, UBE2R2, XRCC5 +2 more | View in SCUBA |
| Hematopoietic progenitor cells | Chromatin Remodeling Stemness | CBX3, EIF3A, EIF5B, GDF11, HNRNPM, NMNAT3, RFX7, RIF1 +4 more | |
| Innate lymphoid cells | Splicing & Transcription RNA processing & translation | ACTR2, BDP1, CDC5L, CYLD, DHX36, FXR1, GPATCH2, MTPN +12 more | View in SCUBA |
| Macrophages | Nuclear Pore Transport Housekeeping | AARS1, APH1A, ARF3, ATG3, CNOT7, CTDNEP1, DCAF7, GNAI2 +18 more | View in SCUBA |
About the gene
| Synonyms | dJ3J17.2, GRY-RBP, hnRNP-Q, HNRNPQ, HNRPQ1, NSAP1 |
|---|---|
| Chromosome | 6: 85607779-85644063 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Ribonucleoprotein, RNA-binding |
| Biological process | Host-virus interaction, mRNA processing, mRNA splicing, Translation regulation |
Function
Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop- containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.