Proteasome ER Proteostasis
Gene co-expression module in Innate lymphoid cells
| Category | Protein processing & ER |
|---|---|
| Genes | 28 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 28 genes have a known function matching the annotation |
Why this annotation
Hub genes with core membership include PSME2 (proteasome activator REG-beta), PSMD8, PSMA7, PSMB1 (proteasome subunits), MANF (ER stress survival factor), SDF2L1 (ER stress/unfolded protein response), SEC61B (ER translocon), SERBP1 (SERPINE1 mRNA binding), SNRPB/SNRPD1 (snRNP). ATP5MC1, ATP5PF (ATP synthase subunits), NDUFB3 (Complex I) add OxPhos. Strong coherence and significant delta_inflammation signal. The proteasome subunits dominate (PSME2, PSMD8, PSMA7, PSMB1) alongside ER stress markers (MANF, SDF2L1, SEC61B), indicating a proteasome-ER proteostasis program. IL4I1 (ILC1 4.3x enriched) is a peripheral member. This is the most coherent proteasome module in the batch.
Genes
ATP5MC1, ATP5PF, DBI, GNG5, GTF3C6, HNRNPK, IL4I1, MANF, MED10, NDUFB3, PA2G4, PRELID1, PSMA7, PSMB1, PSMC4, PSMD8, PSME2, RAN, RHEB, RNASEH2C, SDF2L1, SEC61B, SERBP1, SNRPB, SNRPD1, SPCS2, UBE2L3, ZNHIT1
Most correlated modules
- Mitochondrial Translation · correlation 0.97
- Actin Cytoskeleton Remodeling · correlation 0.95
- RNA Splicing Processing · correlation 0.95
- DNA Damage Response · correlation 0.94
- Endosomal Trafficking Signaling · correlation 0.93
- ER-Golgi Trafficking · correlation 0.93
- TRiC Chaperonin Folding · correlation 0.91
- RNA Chromatin Regulation · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.