Endosomal Trafficking Signaling
Gene co-expression module in Innate lymphoid cells
| Category | Immune regulation |
|---|---|
| Genes | 25 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 25 genes have a known function matching the annotation |
Why this annotation
This module has weak coherence, low mean expression, and low pct positive. Nearly all genes have weak membership scores. Hub genes include RALB (RAS-related GTPase involved in vesicle trafficking and survival signaling), CCDC85B (coiled-coil domain protein), SBNO1 (transcriptional repressor), HAX1 (anti-apoptotic, mitochondria-associated), CKLF (chemokine-like factor), IL27RA (IL-27 receptor, immune regulation), TNFRSF25 (DR3, TNF receptor superfamily member involved in ILC activation), RASSF5 (RAS association domain, apoptosis/adhesion), VPS29 (retromer complex, endosomal trafficking), M6PR (mannose-6-phosphate receptor, lysosomal targeting). The ILC1 enrichment of several genes (RALB, CKLF, IL27RA, TNFRSF25, COMMD8, GDE1, RASSF5, VAMP5) is notable. IL27RA and TNFRSF25 are cytokine/TNF receptor signaling components relevant to ILC/NK biology. The module is weakly coherent and likely represents a mixed program of vesicle trafficking, signaling, and immune receptor expression. The neighbor context (surrounded by other housekeeping/mixed modules) supports a loosely defined signaling/trafficking program. Given the weak coherence and low expression, this is likely a mixed module combining endosomal trafficking with immune receptor signaling.
Genes
ARF1, CCDC85B, CKLF, COMMD8, FAM50A, GDE1, HAX1, IL27RA, LSM8, M6PR, MRPL33, NAA10, PCMT1, PPP3CA, PTPN7, RALB, RAP1A, RASSF5, RNPS1, SBNO1, TMEM248, TNFRSF25, VAMP5, VASP, VPS29
Most correlated modules
- Proteasome ER Proteostasis · correlation 0.93
- Mitochondrial Translation · correlation 0.93
- Actin Cytoskeleton Remodeling · correlation 0.93
- Antigen Processing MHC-I · correlation 0.92
- DNA Damage Response · correlation 0.92
- Innate Inflammatory Activation · correlation 0.91
- RNA Chromatin Regulation · correlation 0.91
- ER-Golgi Trafficking · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.