RNA Chromatin Regulation
Gene co-expression module in Innate lymphoid cells
| Category | RNA processing & translation |
|---|---|
| Genes | 28 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include ACADM (medium-chain acyl-CoA dehydrogenase, fatty acid beta-oxidation), NUP62 (nuclear pore), G3BP1 (stress granule assembly), SLBP (stem-loop binding protein, histone mRNA processing), CBX3 (HP1-gamma, heterochromatin), SRSF10 (splicing factor), SAFB (scaffold attachment factor, RNA processing), PIN1 (prolyl isomerase, cell cycle/transcription), DNAJA2 (Hsp40 co-chaperone), PDCD2 (RNA processing/apoptosis). Nearly all genes show weak membership and the module is moderate coherence. The mix of RNA processing, chromatin regulation, and metabolic genes with no dominant pathway suggests a general housekeeping/RNA processing program. SLBP, CBX3, SRSF10, SAFB, and PDCD2 converge on RNA/chromatin regulation.
Genes
ACADM, AURKAIP1, BUD23, CBX3, CMC2, COPB1, DNAJA2, DYNC1LI1, G3BP1, INPP1, IRF3, NUP62, OCIAD1, PDCD2, PIN1, PUM3, RER1, RSBN1, SAFB, SAR1B, SDF2, SLBP, SNF8, SRSF10, SUDS3, UBXN4, UFD1, UHMK1
Most correlated modules
- DNA Damage Response · correlation 0.94
- TRiC Chaperonin Folding · correlation 0.94
- Mitochondrial Translation · correlation 0.94
- NK JAK3 Signaling · correlation 0.92
- Transcription RNA Processing · correlation 0.92
- Endosomal Trafficking Signaling · correlation 0.91
- Actin Cytoskeleton Dynamics · correlation 0.91
- Proteasome ER Proteostasis · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.