AP-1 Transcriptional Activation
Gene co-expression module in Innate lymphoid cells
| Category | DNA regulation & transcription |
|---|---|
| Genes | 37 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
The core hub gene JUND (AP-1 transcription factor, core membership) anchors this module in transcriptional activation. Supporting genes include TAF10 (TFIID basal transcription), MBD2 (epigenetic reader), KLF13 (KLF family TF), NR1D2 (nuclear receptor involved in circadian and metabolic gene regulation), ALYREF (mRNA export adaptor linking transcription to export), UBE2M (neddylation E2, regulates cullin-RING ligases and transcription factor stability), and CITED2 (CBP/p300-interacting transcriptional coactivator). VEGFB and METRNL suggest some secretory/cytokine output. The uniform expression across subsets and moderate coherence suggest a broadly active transcriptional program. JUND-centered AP-1 activation with epigenetic co-regulators is consistent with a basal or tonic activation transcriptional state in NK/ILC cells.
Genes
AHNAK, ALYREF, CD81, CDV3, CITED4, ESYT2, ETS1, GNAI2, GRK2, HNRNPD, HSPA5, IFFO2, JUND, KLF13, KPNA4, LMNA, MAML2, MAP1LC3B, MBD2, MBNL1, METRNL, MYADM, NFIL3, NR1D2, PRRC2B, PURA, QKI, RBM38, SIK3, SOD2, SRRM2, TAF10, TGFB1, UBALD2, UBE2M, VEGFB, ZCCHC2
Most correlated modules
- ILC3 identity · correlation 0.57
- NF-κB Inflammatory Activation · correlation 0.45
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.