NF-κB Inflammatory Activation
Gene co-expression module in Innate lymphoid cells
| Category | Inflammation |
|---|---|
| Genes | 35 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 15 of 20 genes have a known function matching the annotation |
Why this annotation
This is a highly coherent module (all core/strong memberships) centered on NF-κB and AP-1 transcriptional activation with negative feedback regulators. Key NF-κB pathway genes include NFKBIA (IκBα), TNFAIP3 (A20), NFKBIZ (IκBζ), and ICAM1. AP-1 components include FOS, JUN, and JUNB. Negative regulators of inflammation include DUSP1 (MAPK phosphatase), ZFP36 (mRNA decay of cytokine transcripts), and PPP1R15A (integrated stress response phosphatase). TSC22D3 is a glucocorticoid-induced leucine zipper protein consistent with the positive delta_treatment signal. CDKN1A (p21) and CSRNP1 add a growth arrest/stress TF component. PER1 may reflect circadian regulation of NF-κB. This represents a canonical inflammatory activation program with built-in transcriptional negative feedback, consistent with NK/ILC activation in the inflamed gut.
Genes
CDKN1A, CSRNP1, DUSP1, DUSP2, DUSP6, ELL2, EZR, FOS, ICAM1, IDS, JMY, JUN, JUNB, KLF10, KLF2, KLF6, NFKBIA, NFKBIZ, PER1, PHF1, PNRC1, PPP1R15A, PPP1R15B, PRR7, RHOB, SQSTM1, SSBP2, TNFAIP3, TSC22D3, TSPYL1, TSPYL2, XBP1, ZC3H12A, ZFAND5, ZFP36
Most correlated modules
- AP-1 Transcriptional Activation · correlation 0.45
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.