SRRM2 — Serine/arginine repetitive matrix 2
SRRM2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SRRM2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | mRNA splicing RNA processing | ANKRD11, ARGLU1, CYBC1, LUC7L3, PLCG2, PNN, SON, TCIRG1 +1 more | View in SCUBA |
| CD8⁺ T cells | Pre-mRNA Splicing RNA processing & translation | BRD2, EIF3A, FUS, HNRNPU, HSPA9, NCL, PNN, RBM25 +5 more | View in SCUBA |
| Gamma-delta T cells | MAPK Kinase Signaling TCR Signaling | ARIH1, B4GALT1, BRAF, CDK16, CHD1, DYRK1A, GNA13, KDM2A +8 more | |
| Innate lymphoid cells | AP-1 Transcriptional Activation DNA regulation & transcription | AHNAK, ALYREF, CD81, CDV3, CITED4, ESYT2, ETS1, GNAI2 +28 more | View in SCUBA |
| Macrophages | mRNA Splicing Processing Housekeeping | ACIN1, ARID3A, BOD1L1, CCNL2, CDK12, CLK4, DCP2, GPATCH2L +20 more | View in SCUBA |
| Mucosal-associated invariant T cell | Transcription Factor Activity DNA/chromatin regulation | AKAP17A, BTAF1, HNRNPH1, HSPA9, IKZF5, LCOR, NDEL1, POLR2M +3 more |
About the gene
| Synonyms | Cwc21, KIAA0324, SRL300, SRm300 |
|---|---|
| Chromosome | 16: 2752626-2772538 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | RNA-binding |
| Biological process | mRNA processing, mRNA splicing |
Function
Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.