NK/ILC1 Identity
Gene co-expression module in Innate lymphoid cells
| Category | Differentiation |
|---|---|
| Genes | 26 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 20 genes have a known function matching the annotation |
Why this annotation
GIMAP2 and GIMAP6 are GTPases of the immunity-associated protein family critical for lymphocyte survival and homeostasis. CD96 is an NK inhibitory/co-stimulatory receptor (TIGIT family). ITM2A is expressed during lymphocyte differentiation and marks ILC1/NK identity. CD37 is a tetraspanin expressed on lymphocytes involved in survival signaling. RNF125 is an E3 ubiquitin ligase that negatively regulates innate immune signaling (targets RIG-I, MDA5). CTSD (cathepsin D) is a lysosomal protease. SCML4 is a Polycomb-associated factor. Multiple genes show ILC1 enrichment. The module reflects NK/ILC1 identity, survival, and homeostatic programs.
Genes
ABCA5, ARHGAP15, CD37, CD96, CD99, CTSD, EPC1, GIMAP2, GIMAP6, GSTK1, HSBP1L1, IPCEF1, ITM2A, LRP10, ODF2L, PCDH9, RASA2, RNF125, S100A13, SCML4, SMDT1, SUSD6, TMEM106B, TPST2, TSPAN4, VWA5A
Most correlated modules
- NK Receptor Signaling · correlation 0.81
- Lymphocyte Apoptosis Regulation · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.