ILC1 Cytoskeletal Metabolic
Gene co-expression module in Innate lymphoid cells
| Category | Cytoskeleton & motility |
|---|---|
| Genes | 23 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 23 genes have a known function matching the annotation |
Why this annotation
WDR1 (AIP1) is an actin-depolymerizing factor cofactor that works with cofilin to disassemble actin filaments. PKM is pyruvate kinase M (glycolysis). CCT7 is a chaperonin subunit (TRiC, involved in actin/tubulin folding). SLC25A39 and SLC25A5 (ANT2) are mitochondrial solute carriers. MTCH2 is a mitochondrial outer membrane protein. ATP5F1B is ATP synthase beta subunit. STXBP2 (Munc18-2) is a secretory vesicle fusion regulator critical for NK/ILC cytotoxic granule exocytosis. CD82 is a tetraspanin involved in immune cell signaling and NK cell function. TIMM17B is a mitochondrial inner membrane translocase. GADD45GIP1 is a growth arrest/DNA damage protein. SNRPC is an snRNA-associated protein. RALY is an RNA-binding protein. TNIP1 is an NF-κB inhibitor. HMGA1 is a chromatin architectural protein. DNPH1 is a nucleotide metabolism enzyme. NHP2 is an H/ACA snoRNP component. The module is mixed but notable for WDR1 (actin dynamics), CCT7 (actin/tubulin chaperone), PKM (glycolysis), and STXBP2 (cytotoxic degranulation). The ILC1 enrichment is strong. Given the neighbor context (M24 = actin, M63/M71 = OxPhos/glycolysis), this module likely represents a cytoskeletal-metabolic ILC1 program with a degranulation component. STXBP2 and CD82 add a cytotoxicity flavor.
Genes
ATP5F1B, ATXN10, CCT7, CD82, DNPH1, GADD45GIP1, HMGA1, MEA1, MTCH2, NDUFB1, NHP2, PKM, PPP1CC, RALY, SLC25A39, SLC25A5, SNRPC, STXBP2, TIMM17B, TNIP1, TRAPPC3, WDR1, YIPF3
Most correlated modules
- Proteasome & COPI Trafficking · correlation 0.96
- Mitochondrial OxPhos Biogenesis · correlation 0.95
- Proteasome & TCA · correlation 0.94
- Mitochondrial OxPhos · correlation 0.94
- Oxidative Phosphorylation · correlation 0.94
- Mixed Proteostasis Metabolism · correlation 0.93
- Glycolysis & OxPhos · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.